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Web(6-TGN), which represent active metabolites (Figure 1).21, 27, 28 While thiopurines are inactive molecules with a half-life of about 1–2 h, therapeutic response is related to 6-TGN production and accumula-tion.29 In vivo, 6-TGN steady-state is approximately achieved in 4–5 weeks and their half-life is between 3 days WebTGN Productions. Media & Internet · New York, United States · <25 Employees . TGN Productions specializes in Events, Surprise Proposals, Portraits, Family Portraits, and … Web27 Jan 2024 · 6-Thioguanine nucleotide (6-TGN) is the active metabolite of thiopurine drugs azathioprine and 6-mercaptopurine. 6-Methylmercaptopurine (6-MMP) is an inactive and potentially hepatotoxic metabolite. A subgroup of patients (shunters) preferentially produce 6-MMP instead of 6-TGN, therefore displaying thiopurine resistance and risk for … riverside bakery mchenry illinois