Cisplatin hearing loss data
WebAtorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer Latest version (submitted April 11, 2024) on ClinicalTrials.gov A study version is represented by a row in the table. Select two study versions to compare. One each from columns A and B. WebFeb 13, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not …
Cisplatin hearing loss data
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WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by …
WebApr 6, 2016 · Significance statement: Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. Its use results in significant and permanent hearing loss, for which no US Food and Drug Administration-approved treatment is currently available. WebSep 21, 2016 · Individually, children in this series first showed decreases in hearing after cumulative cisplatin doses ranging between 75 and 600 mg/m 2 and carboplatin doses between 800 and 3,420 mg/m 2. Patients treated for germ cell tumors (Children's Oncology Group 8882) received the highest cumulative doses of cisplatin.
WebSigns and symptoms seen in children as ototoxicity develops include: High-frequency (≥4 kHz) sensorineural hearing loss that is bilateral (affecting both sides), progressive, and … WebJul 13, 2024 · Hearing loss can have significant long-term consequences for children treated for cancer, said Edward Neuwelt, M.D., of Oregon Health & Science University, who helped lead both recent trials. “Around 60% to …
WebJun 1, 2024 · Overall, for all cancers treated with cisplatin, the incidence of hearing loss is about 50%. But some specific cancers, especially children who have cancers in very early childhood—say, younger than 5 years old—tend to have a more severe cisplatin-induced hearing loss and at a higher incidence.
WebJan 26, 2024 · But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant … bison high school sdWebMar 29, 2024 · This hearing disorder results from temporary or permanent inner ear dysfunction, typically causing bilateral high-frequency sensorineural hearing loss that progresses to lower frequencies with continued exposure. 3 The risk of permanent bilateral sensorineural hearing loss and tinnitus can occur both during treatment and long-term … bison high schoolWeb顺铂治疗导致的永久性听力损失率在 40% 到 80% 之间，并且与相当大的发病率和对生活质量的负面影响有关。 目前，没有 FDA 批准的预防顺铂引起的听力损失的疗法。 HMG-CoA 还原酶抑制剂（他汀类药物）由于假定的多效性作用、减少炎症和氧化应激而受到关注。 一些临床前和回顾性研究表明，同时服用他汀类药物可以减少顺铂相关的听力损失。 目的： … bison hierarchyWebModern research on ototoxicity goes back to the 1940s, when streptomycin was introduced into clinical practice. Today, aminoglycoside antibiotics and platinum-based chemotherapy, mainly cisplatin, are the most important drugs that … darrell johnson north myrtle beachWebFeb 11, 2024 · Cisplatin-induced hearing loss (CIHL) is a debilitating toxicity commonly experienced by patients who received cisplatin … bison high tackWebFeb 15, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not all treatment schedules came with the same risk. bison high tack expressWebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease … bison high school south dakota